Program

Monday
April 14, 2025

Tuesday
April 15, 2025

Monday, April 14, 2025		Meeting Room
7:00 am – 5:00 pm	Registration Table	King Arthur Foyer (third floor)
7:30 am – 8:30 am	Breakfast	Camelot Ballroom (third floor)
8:00 am – 8:25 am	CSCTR Membership Meeting David Kennedy, PhD President, CSCTR Associate Professor of Medicine University of Toledo College of Medicine and Life Sciences	Streeterville Room (ground floor)
8:30 am – 8:40 am	Welcome and Opening Remarks David Kennedy, PhD President, CSCTR Associate Professor of Medicine University of Toledo College of Medicine and Life Sciences Jeffrey Salomon, MD, MBA Councilor, CSCTR Midwestern Chair, AFMR Midwestern Region Pediatric Critical Care Medicine Physician University of Nebraska Medical Center	King Arthur Court (third floor)
8:45 am – 10:45 am	MWAFMR Career Development Workshop Moderators: Laneshia Tague, MD, MSCI Secretary-Treasurer, AFMR Midwestern Region Assistant Professor of Medicine Washington University in Saint Louis Jennifer Alexander-Brett, MD, PhD President-Elect, CSCTR Past Chair, AFMR Midwestern Region Assistant Professor of Medicine Washington University School of Medicine in St. Louis Bella Z. Khatib-Shahidi, BS Medical Student University of Toledo College of Medicine and Life Sciences Speakers: Building Your Research Network This talk will emphasize the importance of building a research network as part of career development/advancement and guidance on how to do that successfully. Dr. Mikuls will share some personal experiences with the VARA group and mentoring in that context. Ted R. Mikuls, MD, MSPH Stokes-Shackleford Professor of Rheumatology University of Nebraska Medical Center Vinayak Prasad, MD, MPH Professor, Epidemiology & Biostatistics University of California, San Francisco School of Medicine Using Aggregated, De-identified Electronic Health Record Data for Scientific Discovery In this session viewers gain exposure to aggregated, de-identified electronic health record data tools, especially TriNetX and Epic's Cosmos Data Network. They will learn what these tools are and how the hundreds of millions of patients' data in these tools can be used for scientific discovery. David Kaelber, MD, PhD, MPH, FAAP, FACP Associate Professor Case Western Reserve School of Medicine Department of Population and Quantitative Health	King Arthur Court (third floor)
10:45 am – 11:00 am	Coffee Break	Camelot Ballroom (third floor)
11:00 am – 12:30 pm	New Investigator Session Moderator: Suthat Liangpunsakul, MD, MPH Past President, CSCTR Professor of Medicine Indiana University School of Medicine Prabhatchandra Dube, PhD Research Associate University of Toledo College of Medicine and Life Sciences Presenters: Outstanding Young Investigator PDK4-Mediated Formation of the Ca2+-Channeling Complex at the ER-Mitochondria Interface Contributes to the Development of Alcohol-Associated Liver Disease Mitochondrial dysfunction played a central role in alcohol-associated liver disease (ALD), with Ca²⁺ overload-induced mitochondrial damage as a key mechanism. The formation of mitochondria-associated endoplasmic reticulum (MAM) membranes, which facilitated the transfer of Ca²⁺ from the ER to mitochondria, contributed to mitochondrial Ca²⁺ accumulation and dysfunction. However, the exact mechanisms underlying mitochondrial Ca²⁺ accumulation in ALD remained poorly understood. In this study, we explored the role of MAMs in ALD pathogenesis. We found that alcohol enhanced MAM formation, promoting the formation of a MAM Ca²⁺-channeling complex (MCCC) composed of IP3R1, VDAC1, and GRP75. Additionally, we demonstrated that the MAM-associated protein pyruvate dehydrogenase kinase 4 (PDK4) regulated MCCC formation by phosphorylating GRP75, leading to mitochondrial Ca²⁺ overload, mitochondrial dysfunction, and liver injury. These findings highlighted PDK4 as a potential therapeutic target for ALD and offered new insights into the pathogenesis and treatment of this increasingly prevalent condition. Themis Thoudam, PhD Division of Gastroenterology and Hepatology Indiana University School of Medicine 2023 Early Career Development Awardee Mapping the Neural Circuits that Drive Stress-Induced Hyperglycemia During critical illness, glucose mobilization leads to “stress-hyperglycemia”, an adaptive process that promotes survival. Both inadequate and excessive glucose mobilization is associated with increased in-hospital mortality and the precise glycemic target for each individual is unknown. Achieving the appropriate degree of glucose mobilization during stressful situations depends on central nervous system coordination of the various components of the glycemic response to stress, including HPA axis activation and catecholamine release. We have identified distinct populations of neurons in the hypothalamus that control different glycemic stress response components, indicating that optimal stress hyperglycemia is coordinated across multiple neural circuits. These findings lay the groundwork for establishing the specific mechanisms through which the brain coordinates glucose mobilization during stress, a key step in identifying targeted treatments for managing stress hyperglycemia. Alison Affinati, MD, PhD Assistant Professor University of Michigan 2024 Early Career Development Awardees Distinct Histopathological Phenotypes of Severe Alcoholic Hepatitis Suggest Different Mechanisms Driving Liver Injury and Failure Our study identifies distinct patterns of hepatic inflammatory cell infiltration in patients with severe alcoholic hepatitis (SAH), linking neutrophil infiltration to disease severity. Hepatic neutrophil cytosolic factor 1 (NCF1) is upregulated in SAH and correlates with neutrophil presence. Using Ncf1 knockout mice, the study shows that loss of Ncf1 reduces neutrophil accumulation, liver injury, and inflammation in ethanol-induced liver injury. Jing Ma, MD, PhD Assistant Research Professor of Medicine Indiana University School of Medicine Preventing Cardiovascular Disease in South Asians: A New Focus on the 2nd Generation People of South Asian ethnicity experience high rates of cardiovascular disease and excess burden of cardiovascular and metabolic risk factors at younger ages compared with other groups. Reasons for this disproportionately high prevalence of cardiovascular diseases remain under investigation. In the United States, the 2nd generation South Asian community is rapidly growing. Dr. Shah's research focuses on understanding earlier-life development of cardiovascular risk factors in this population, with a goal to develop and implement adapted and contextualized cardiovascular disease prevention strategies across the life course. Nilay Shah, MD, MPH Assistant Professor Northwestern University Feinberg School of Medicine Skeletal muscle regulation of hepatic responses Hepatocellular cancer (HCC) is a malignancy with a poor outcome with limited preventive approaches. Cirrhosis remains the major risk factor for HCC, and both cirrhosis and HCC are associated with sarcopenia, a frequent complication of liver disease and cirrhosis. A number of interventions have been suggested to reverse sarcopenia in liver disease by targeting the mediator(s) of the liver-muscle axis. Our preliminary studies in vivo in preclinical models have shown that skeletal muscle can regulate hepatic biological processes, including hepatic fibrosis and steatosis, risk factors for HCC. We have previously reported that myostatin, a transforming growth factor beta superfamily member, mediates sarcopenia in liver disease. Conditioned medium from murine C2C12 myotubes with depletion of myostatin and increased protein synthesis and myotube diameter decreased murine HCC cell proliferation and viability. We also observed less muscle expression of myostatin in voluntary wheel running (VWR) than in usual activity mice. Interestingly, others have reported that hyperammonemia (a consistent metabolic perturbation in cirrhosis) caused increased hepatic stellate cell activation and collagen deposition and we have shown that hyperammonemia is a mediator of the liver muscle axis. We also observed that muscle molecular, metabolic, functional, and multiomics responses to hyperammonemia were reversed by VWR. Additionally, gut dysbiosis, which is also believed to contribute to HCC, was reversed by VWR. Perivenous fibrosis during hyperammonemia in mice was also reversed by VWR. These data provide the mechanistic basis for the clinical observation of beneficial responses of exercise to lower HCC prevalence in humans. Our ongoing studies in mice with muscle-specific deletion of myostatin with intraperitoneal diethylnitrosamine (DEN) with a high-fat diet and VWR mice with DEN/HFD, will provide the rationale for exercise-induced beneficial responses via myoexerkines, including less myostatin expression in skeletal muscle. These transformative studies are likely to be a novel strategy for HCC prevention in cirrhosis while simultaneously restoring skeletal muscle mass. Nicole Welch, MD Assistant Professor of Medicine Cleveland Clinic Lerner College of Medicine	King Arthur Court (third floor)
12:30 pm – 1:15 pm	Lunch	Camelot Ballroom (third floor)
1:00 pm - 5:00 pm	Setup posters for Monday, April 14th 5:30 pm session	Avenue Ballroom (ground floor)
1:15 pm – 2:15 pm	Department Chair Session Moderators: Steven Dudek, MD Past President, CSCTR Professor of Medicine University Illinois at Chicago Sudheer Dhoop, MD Chief Resident Internal Medicine Residency Program University of Toledo College of Medicine and Life Sciences Speakers: Advancing Medical Research: Innovations and Insights from Junior Faculty at UIC This session will showcase innovative research by three junior faculty members in the Department of Medicine. This session will feature diverse topics spanning translational medicine, clinical research, and novel therapeutic strategies, highlighting the latest advancements in patient care and medical science. Each presenter will share their expertise, findings, and future directions. Whether you are a researcher, clinician, or student, this event offers a unique opportunity to engage with emerging leaders in the field and explore the future of medical research. Rachel Caskey, MD, MPP Earl M. Bane Professor and Head Department of Medicine University of Illinois Chicago Sarah Messmer, MD Assistant Professor of Medicine and Pediatrics University of Illinois Chicago Marcos Munoz, PhD Assistant Professor University of Illinois Chicago Andrea A. Pappalardo, MD Associate Professor of Medicine and Pediatrics University of Illinois Chicago	King Arthur Court (third floor)
2:15 pm – 2:25 pm	Coffee Break	Camelot Ballroom (third floor)
2:25 pm – 3:25 pm	Cardiology/Pulmonary Lecture Moderators: Jeffrey Salomon, MD, MBA Councilor, CSCTR Midwestern Chair, AFMR Midwestern Region Pediatric Critical Care Medicine Physician University of Nebraska Medical Center Vaish Aradhyula, MS, BS Fourth-year MD/MBA Student University of Toledo College of Medicine Speaker: Ram Kumar Subramanyan, MD, PhD, FACS Chief, Pediatric Cardiothoracic Surgery Professor of Surgery Children's Nebraska/University Nebraska Medical Center	King Arthur Court (third floor)
3:25 pm – 3:35 pm	Coffee Break	Camelot Ballroom (third floor)
	*Concurrent Sessions:
*3:35 pm – 4:30 pm	Annual Max Miller Lecture in Diabetes Research Moderators: Dawn Belt Davis, MD, PhD Past President, CSCTR Professor University of Wisconsin – Madison Anupam Kotwal, MBBS, MSc Past Chair, AFMR Midwestern Region Assistant Professor of Medicine University of Nebraska Medical Center Heidi Christian, MD, MS Pathology Resident University of Illinois Hospital and Health Sciences System Speaker: Mitochondria and the regulation of pancreatic beta cell fate Type 1 and type 2 diabetes, the most common forms of the disease, share the common pathology of dysfunctional insulin-producing pancreatic beta cells. Despite their roles in energy production in beta cells and other metabolic tissues, how abnormal mitochondria contribute to diabetes remains unclear. In this lecture, new paradigms of the importance of mitochondria in the fate of metabolic tissues will be discussed, including methods to overcome damaged mitochondria in diabetes and how to target mitochondria to enhance beta cell formation to treat diabetes. Scott Soleimanpour, MD Associate Professor Director of the Michigan Diabetes Research Center University of Michigan	Streeterville Room (ground floor)
*3:35 pm – 4:30 pm	Inflammation, Immunity, and Transplant Moderators: Suman Setty, MBBS, PhD Councilor, CSCTR Associate Professor of Pathology University of Illinois at Chicago Syed Bukhari, MD, MSc Chair-Elect, AFMR Midwestern Region Vascular Medicine Fellow Cleveland Clinic Ruchi Naik, MD, PhD Assistant Professor of Clinical Medicine Fellowship Director- Transplant Nephrology University of Illinois Chicago Speakers: Recent Insights into the Role of Neutrophils in Primary Graft Dysfunction after Lung Transplantation This lecture will discuss neutrophil-dependent mechanisms of lung ischemia-reperfusion injury that contribute to primary graft dysfunction (PGD) after lung transplantation. Emphasis will be placed on recent advances in neutrophil extracellular traps, neutrophil metabolism, and neutrophil heterogeneity, and how these preclinical insights could be leveraged to develop novel neutrophil-directed therapies for PGD. Davide Scozzi, MD, PhD Assistant Professor Norton Thoracic Institute at the St. Joseph`s Hospital and Medical Center Creighton University School of Medicine Tales from the gut: Novel strategy to mitigate complications in short bowel syndrome Ajay Jain, MD Professor of Pediatrics, Pharmacology and Physiology Director MD/PhD Program, School of Medicine Saint Louis University	King Arthur Court (third floor)
4:40 pm - 5:25 pm	Dissemination and Implementation Science Session Moderators: Leena Bhattacharya Mithal, MD Associate Professor, Pediatrics (Infectious Diseases) Northwestern University Jerry A. Krishnan, MD, PhD Past President, CSCTR Associate Vice Chancellor for Population Health Sciences Professor of Medicine and Public Health Epidemiology and Biostatistics University of Illinois Chicago Speaker: Beginning with the End in Mind: Designing for Dissemination and Sustainability Translational science seeks to advance the implementation process of turning observations in the laboratory, clinic and community into interventions that improve the health of individuals and the public. This lecture will discuss a new implementation science framework: Designing for Dissemination and Sustainability (D4DS). This approach actively engages stakeholders in the design of interventions, policies or programs to ultimately increase their adoption, sustainability, and impact on health and health equity. D4DS is a continuous and iterative Fit-to-Context validation approach that occurs throughout Conceptualization, Design, Dissemination and Impact translational phases. Case application to implementing and sustaining a national Electronic Health Record research network will be reviewed. Elaine Morrato, DrPH, MPH, FISPE, CPH Professor Dean of the Parkinson School of Health Sciences and Public Health Loyola University Chicago	King Arthur Court (third floor)
5:30 pm – 6:45 pm	Opening Reception and Moderated Poster Discussions Wine, Beer, and Appetizers Served David Kennedy, PhD President, CSCTR Associate Professor of Medicine University of Toledo College of Medicine and Life Sciences Jeffrey Salomon, MD, MBA Councilor, CSCTR Midwestern Chair, AFMR Midwestern Region Pediatric Critical Care Medicine Physician University of Nebraska Medical Center Poster Research Categories Click on a category to view abstracts. Case Reports T0 Research/Science T1 Research/Science T2 Research/Science T3 Research/Science T4 Research/Science	Avenue Ballroom (ground floor)
6:45 pm	Dinner (on your own)
Tuesday, April 15, 2025		Meeting Room
7:00 am – 3:30 pm	Registration Table	King Arthur Foyer (third floor)
7:00 am – Noon	Setup posters for Tuesday, April 15th, 1:45 pm session	Avenue Ballroom (ground floor)
7:30 am – 8:30 am 8:00 am Table Switch	Mentor and Attendee Breakfast Navigating the Maze: Mastering Human Subjects Research Policies (for Clinical and Translational Research Staff and Investigators) Mentor: Laneshia Tague, MD, MSCI and Mario Castro, MD, MPH Research Harmony: 7 Habits of Highly Effective Research Managers (for Clinical and Translational Research Staff and Investigators) Mentor: Lynn B. Gerald, PhD, MSPH and Syed Bukhari, MD Rise to the Top: Securing Leadership Roles in Regional & National Committees Mentor: Attaya Suvannasankha, MD and Jennifer Alexander-Brett, MD, PhD Priority Power: Mastering Communication & Negotiation for Success Mentor: Jerry A. Krishnan, MD, PhD and Steven Dudek, MD Mentor Match: Building Strong, Lasting Mentor/Mentee Relationships Mentor: Anupam Kotwal, MBBS, MSc and David J. Kennedy, PhD Women Who Balance: Thriving in Medicine & Science Mentor: Tara G. Mehta, PhD and Sara Becker, PhD Case Closed: Evolving from Case Reporter to Clinical Investigator Mentor: Jeffrey Salomon, MD and Suthat Liangpunsakul, MD, MPH	Camelot Ballroom (third floor)
7:30 am – 8:30 am 8:00 am Table Switch
8:45 am – 9:45 am	AFMR Keynote Presentation Moderators: Jeffrey Salomon, MD, MBA Councilor, CSCTR Midwestern Chair, AFMR Midwestern Region Pediatric Critical Care Medicine Physician University of Nebraska Medical Center Rajan Mediratta, MD First-Year Resident Loyola University Medical Center Speaker: Genomics-driven Identification of Novel Targets and AI-based Discovery of Drug Compounds for Lung Cancer Overall, the lecture is on drug discovery, and it covers advances in precision medicine using genomics and AI-driven technologies. Lung cancer datasets were used in this study due to their availability in the public domain, however, the methodologies are broadly applicable to all domains that have appropriate genomics datasets. Chittibabu (Babu) Guda, PhD Professor Co-Director, Center for Biomedical Informatics Research and Innovation University of Nebraska Medical Center	King Arthur Court (third floor)
9:45 am – 10:00 am	Coffee Break	Camelot Ballroom (third floor)
10:00 am – 11:00 am	Health Equity Session Moderators: Laneshia Tague, MD, MSCI Secretary-Treasurer, AFMR Midwestern Region Assistant Professor of Medicine Washington University in Saint Louis David Kennedy, PhD President, CSCTR Associate Professor of Medicine University of Toledo College of Medicine and Life Sciences Jonnelle Edwards-Glenn, PhD Postdoctoral Scholar Case Western Reserve University School of Medicine Speakers: Community engagement with hyper-local air pollution monitoring in an industrialized neighborhood on Chicago's far southeast side Christopher Olopade, MD, MPH Professor of Family Medicine Professor of Medicine The University of Chicago Medical Center Preliminary findings on the environment in the All of Research Program We have conducted linkages of air and water pollutants into the All of Us Research program and have some interesting results on PM2.5, lithium, and radon. Preliminary findings will be presented with a discussion of future opportunities and directions. Briseis Aschebrook-Kilfoy, PhD, MPH Professor of Family Medicine/Public Health Sciences The University of Chicago	King Arthur Court (third floor)
11:00 am – 11:30 am	Award Ceremony Outstanding Young Investigator Award Themis Thoudam, PhD Oral Abstract Awards Christian Ascoli, MD Shelbi Erp, MD Ghandi F. Hassan, MD Kelsey Holbert, MD Andrew O. Kearney, BA Mohammed I. Lone Sara Osorio-Valencia Zhihong Yang John Q. Yap, PhD Travel Awards Jazzmyn Dawes, BS David Doss Nikhil Furtado, BS Smriti Gurung, PhD Adrienne Johnson, PhD Ranjana K. Kanchan, PhD Ignacio Ruiz-Sanchez Upasana Shrestha, BS Ava Wilson, PhD, MSPH Top Three Poster Abstracts in each Research Category Case Reports Olaniyi Fadeyi Israr Khan, MD David G. Gonzalez Sanchez, MD T0 Research/Science Prabhatchandra Dube, PhD Mariam Khwaja, BS Mehruba Zaman, BS T1 Research/Science Helena Ikenberry Jane Nakamura Christen Vagts, MD T2 Research/Science Sarah Darski, MPH Aidan Faller, BS Denise Kent, PhD, APRN T3 Research/Science Angela C. Judd, MD Alex J. Kloster, MD Angelica Scanzera, OD, MPH T4 Research/Science Danyal Butt, MD Ines Gonzalez Casanova, PhD Megan E. Peterson, MPH, RN	King Arthur Court (third floor)
11:30 am – 12:30 pm	Lunch	Camelot Ballroom (third floor)
12:30 pm – 1:30 pm	CSCTR John B. Hickam Endowed Lecture The John B. Hickam Endowed Lectureship was established in 1981 to honor John Hickam, President of CSCR in 1970. At the time of his death in 1970, Dr. Hickam was Chair of Medicine at Indiana University School of Medicine. Dr. Hickam was internationally recognized in medical research, particularly in the areas of lung, heart and circulatory system diseases. Dr. Hickam was also responsible for the administration of research programs, which established the Indiana University School of Medicine as one of the nation’s primary centers for research in heart disease. Moderator: Jennifer Alexander-Brett, MD, PhD President-Elect, CSCTR Past Chair, AFMR Midwestern Region Assistant Professor of Medicine Washington University School of Medicine in St. Louis Speaker: Two Decades of Progress in Understanding Progressive Pulmonary Fibrosis Dr. Blackwell will describe progress in studying progressive pulmonary fibrosis that has led to our current understanding of underlying mechanisms, genetic and environmental risk factors, and therapeutic targets for this disease. Timothy Blackwell, MD John G. Searle Professor Chair, Department of Internal Medicine University of Michigan	King Arthur Court (third floor)
1:30 pm – 2:00 pm	Catalyzing Collaboration: Transforming Clinical and Translational Research Through Industry and Academic Partnerships Join this new session that explores innovative collaborations between academia and industry aimed at accelerating research breakthroughs. Gain insights from successful partnerships, learn strategies for effective collaboration, and discover how working together can address pressing challenges and drive innovation in clinical and translational research. Moderators: Jennifer Alexander-Brett, MD, PhD President-Elect, CSCTR Past Chair, AFMR Midwestern Region Assistant Professor of Medicine Washington University School of Medicine in St. Louis Jerry A. Krishnan, MD, PhD Past President, CSCTR Associate Vice Chancellor for Population Health Sciences Professor of Medicine and Public Health Epidemiology and Biostatistics University of Illinois Chicago	King Arthur Court (third floor)
2:00 pm - 2:10 pm	Coffee Break	Camelot Ballroom (third floor)
2:10 pm – 3:20 pm	Moderated Poster Discussions Click on a category to view abstracts. Case Reports T0 Research/Science T1 Research/Science T2 Research/Science T3 Research/Science T4 Research/Science	Avenue Ballroom (ground floor)
3:20 pm – 3:30 pm	Coffee Break	Camelot Ballroom (third floor)
3:30 pm – 4:45 pm	Translational Science Oral Session I: Pulmonary, Critical Care, Cardiology, and Renal Moderators: Jeffrey Salomon, MD, MBA Councilor, CSCTR Midwestern Chair, AFMR Midwestern Region Pediatric Critical Care Medicine Physician University of Nebraska Medical Center Laneshia Tague, MD, MSCI Secretary-Treasurer, AFMR Midwestern Region Assistant Professor of Medicine Washington University in Saint Louis Oral Presenters:	King Arthur Court (third floor)
3:30 pm	ADDITION OF PATHOLOGIC FLOW TO HEMIN-TREATED PULMONARY ARTERY ENDOTHELIAL CELLS IMPLICATES DISTINCT TRANSCRIPTOMIC PATTERNS IN SICKLE CELL DISEASE ASSOCIATED PULMONARY HYPERTENSION Kelsey Holbert, MD University of Illinois Chicago
3:42 pm	MITOCHONDRIAL METABOLIC REGULATOR PYRUVATE DEHYDROGENASE KINASE 4 (PDK4) MEDIATES SEX-SPECIFIC CARDIAC RESPONSE TO ENDOTOXEMIA John Q. Yap, PhD Loyola University Chicago
3:54 pm	SPATIAL TRANSCRIPTOMICS INSIGHTS ACROSS A SPECTRUM OF AIRWAY DISEASES Ghandi F. Hassan, MD Washington University in St Louis
4:06 pm	THE IMMUNE LANDSCAPE OF INTRATHORACIC LYMPH NODES IS ASSOCIATED WITH THE LYMPHOPENIC IMMUNOTYPE IN SARCOIDOSIS Christian Ascoli, MD University of Illinois at Chicago
4:18 pm	THE EFFECT OF NICOTINE DELIVERY SYSTEM ON EXTRACELLULAR MATRIX BLOOD PROTEASE LEVELS: A RANDOMIZED CROSSOVER DESIGN Ava Wilson, PhD, MSPH Kansas University Medical Center
4:30 pm	DISPARITIES IN TIMING AND DEMOGRAPHICS OF WITHDRAWAL OF LIFE-SUSTAINING THERAPY FOLLOWING IN-HOSPITAL AND OUT-OF-HOSPITAL CARDIAC ARRESTS Shelbi Erp, MD University of Illinois Chicago
3:30 pm – 4:45 pm	Translational Science Oral Session II: Endocrine/Metabolism, Gastroenterology Moderators: Rochelle N. Naylor, MD Associate Professor of Pediatrics and Medicine The University of Chicago Medicine Suthat Liangpunsakul, MD, MPH Past President, CSCTR Professor of Medicine Indiana University School of Medicine Oral Presenters:	Streeterville Room (ground floor)
3:30 pm	ROLE OF PHOSPHATIDYLETHANOLAMINE METHYLTRANSFERASE (PEMT) IN METABOLIC DYSFUNCTION-ASSOCIATED STEATOHEPATITIS (MASH) Sara Osorio-Valencia University of Illinois Chicago
3:42 pm	KNOCKDOWN FAS ASSOCIATED FACTOR FAMILY MEMBER 2 PREVENTS ALCOHOL-ASSOCIATED LIVER DISEASE Zhihong Yang Indiana University
3:54 pm	MICROPUNCTURE-EXOSOMES DISPLAY AN ENHANCED IMMUNOANGIOGENIC PAYLOAD Jazzmyn Dawes, BS Penn State College of Medicine
4:06 pm	APOL1 KIDNEY DISEASE VARIANTS ALTER FAT DEPOSITION IN A SEX-SPECIFIC MANNER Andrew O. Kearney, BA Northwestern University
4:18 pm	MOTIVATING CHANGE IN OLDER ADULTS: A PILOT STUDY OF MOTIVATIONAL MESSAGES TO PROMOTE QUITTING SMOKING Adrienne L. Johnson, PhD University of Wisconsin School of Medicine and Public Health
4:30 pm	MENTAL HEALTH SCREENINGS IN THE ED: CHRONIC TRAITS OR TEMPORARY STATES? Mohammed I. Lone UChicago Medicine
3:30 pm – 4:45 pm	Translational Science Oral Session III: Hematology/Oncology, Rheumatology/Immunology and Neurology Moderators: Jennifer Alexander-Brett, MD, PhD President-Elect, CSCTR Past Chair, AFMR Midwestern Region Assistant Professor of Medicine Washington University School of Medicine in St. Louis John D. Dickinson, MD, PhD Associate Professor of Medicine University of Nebraska Medical Center Oral Presenters:	St. Clair (upper fifth floor)
3:30 pm	CONTRIBUTION OF GONADAL VERSUS CHROMOSOMAL SEX TO EARLY LIFE STRESS-INDUCED SEXUALLY DIMORPHIC TOURETTE SYNDROME-RELEVANT PATHOLOGY Ignacio Ruiz-Sanchez Yale University
3:42 pm	CYTOTOXIC AND PRO-INFLAMMATORY EFFECTS OF MICROPLASTICS AND MICROCYSTIN TOXIN ON HUMAN AIRWAY EPITHELIAL CELLS Upasana Shrestha, BS The University of Toledo
3:54 pm	NORTRIPTYLINE: A REPURPOSABLE ADJUVANT TO CHEMOTHERAPY IN GROUP 3 MEDULLOBLASTOMA THAT TRIGGERS APOPTOSIS BY INDUCING MITOCHONDRIAL DYSFUNCTION David Doss Creighton University School of Medicine
4:06 pm	TARGETING THE ABCB7/GPX4 AXIS USING ARTESUNATE POTENTIATES CISPLATIN RESPONSE IN PEDIATRIC GROUP 3 MEDULLOBLASTOMAS BY TRIGGERING FERROPTOSIS Ranjana K. Kanchan, PhD University of Nebraska Medical Center
4:18 pm	SOCIOECONOMIC AND DEMOGRAPHIC DISPARITIES IN TREATMENT AND SURVIVAL OF OVARIAN SEROMUCINOUS CARCINOMA: A NATIONAL CANCER DATABASE STUDY Nikhil Furtado, BS Creighton University School of Medicine
4:30 pm	ENHANCING IMMUNOTHERAPY EFFICACY IN MYELOMA WITH A DUAL-ACTION MITOCHONDRIAL-TOXIC PEPTIDE THAT ACTIVATES T CELLS AND INDUCES TUMOR CELL DEATH Smriti Gurung, PhD Indiana University
4:45 pm – 5:45 pm	Closing Reception Wine, Beer, and Appetizers Served David Kennedy, PhD President, CSCTR Associate Professor of Medicine University of Toledo College of Medicine and Life Sciences Jeffrey Salomon, MD, MBA Councilor, CSCTR Midwestern Chair, AFMR Midwestern Region Pediatric Critical Care Medicine Physician University of Nebraska Medical Center	Camelot Ballroom (third floor)